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Crestor – selective inhibitor of q. The main effect of Crestor is directed to the liver, where the synthesis and catabolism of cholesterol.
Crestor increases the number of receptors on the surface of hepatic cells.
Crestor reduces elevated concentrations of cholesterol and reduces the concentration of apolipoprotein B.
The therapeutic effect develops within 1 week after initiation of therapy with Crestor, the maximum possible effect – 2 weeks. The maximum therapeutic effect is achieved at week 4 of treatment Crestor and maintained with regular dosing.
Pharmacokinetic parameters did not change when taken daily.
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Crestor effective in adult patients with hypercholesterolemia, regardless of race, sex or age, including patients with diabetes.
In 435 patients with heterozygous familial hypercholesterolemia receiving Crestor 20-80 mg per day, positive dynamics of lipid profile.
Our studies have JUPITER 17,800 patients showed that Crestor significantly reduced the risk of cardiovascular complications, with a relative risk reduction of 44%. The efficacy of treatment was noted after 6 months of use of the drug.
It decreased by 48% criteria including death from cardiovascular causes, stroke and myocardial infarction, a decrease of 54% of fatal or non-fatal myocardial infarction by 48% – a fatal or non-fatal stroke. Overall mortality decreased by 20%.
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Subject to restrictions metabolism – by 10%. Crestor, metabolic substrate for the cytochrome P450 system. The main isoenzyme involved in the metabolism of Crestor, a CYP2C9. Isozyme CYP2C19, CYP3A4 and CYP2D6 are involved in metabolism less.
The main metabolites identified Crestor are N-desmethyl, lactone metabolites. N-desmethyl by about 50% less active than Crestor, lactone metabolites are pharmacologically inactive.
Cmax Crestor plasma levels achieved approximately 5 hours after oral administration. The absolute bioavailability of approximately 20%.
Crestor is metabolized primarily by the liver, which is the main site of cholesterol synthesis. Approximately 90% Crestor binds to plasma proteins, mainly albumin.
About 90% of Crestor dose excreted unchanged through the intestines. 10% Crestor excreted by the kidneys.
T1 / 2 is 18 – 19 hours. T1 / 2 does not change with increasing dose.
Gender and age did not have a clinically meaningful effect on the pharmacokinetics of buy Crestor.
The form of preparation:
Crestor – 10 mg Tablets, 20 mg:
– Hypersensitivity to Crestor or any component of the drug
– Liver disease
– Renal dysfunction
– Concomitant use of Crestor and cyclosporin
– stomach ache
– Asthenic syndrome
Take a pill Crestor inside, not liquid, and without damaging the tablet is swallowed whole with a glass of clean water.
The drug is taken at any time, regardless of the meal.
Before starting therapy with Crestor the patient should follow a diet and during treatment.
The dose should be individualized by your doctor, depending on the type of treatment.
The recommended starting dose for the main number of patients, should be 5 or Crestor 10 mg 1 time a day.
When selecting the starting dose should be guided by an individual concentration of cholesterol and take into account the possible risk of cardiovascular complications. It is also necessary to evaluate the potential risk of side effects. The dose may be increased.
Recommended especially careful medical supervision, of patients receiving the drug at a dose of 40 mg per day.
Not recommended the appointment of Crestor 40mg dose in patients not previously taking the drug.
If you want to order a drug Crestor – Your doctor should approve the idea, and assign the appropriate dosage.
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