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On this page you will find general information about the drug Ezetimibe and will be able to get acquainted with the main features of the drug.
Before you buy Ezetimibe – be sure to tell your doctor and do all the tests!
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Features of the product:
Ezetimibe selectively inhibits the absorption of cholesterol and some plant sterols in the intestine.
When entering the small intestine Ezetimibe localizes in the small intestine and prevents the absorption of cholesterol. The effect reduces revenues of cholesterol from the intestine to the liver. Ezetimibe does not increase the excretion of bile acids does not inhibit cholesterol synthesis in the liver.
By reducing the absorption of cholesterol in the intestine, Ezetimibe reduces its delivery to the liver.
Clinical studies have shown that elevated levels of total cholesterol and apolipoprotein-B contributes to atherosclerosis. In addition, decreased level of cholesterol associated with the development of atherosclerosis.
Epidemiological studies have established that cardiovascular morbidity and mortality are directly dependent on the level of total cholesterol.
In preclinical studies – it proved that Ezetimibe inhibits absorption of 14C-cholesterol, has no effect on the absorption of triglycerides, fatty acids, bile acids, vitamins A and D.
Indications of the drug:
The drug is indicated for the reduction of elevated total cholesterol.
At elevated levels of plant sterols in the plasma.
Treatment and Dose:
Before and during treatment, patients should follow a diet.
The recommended dose in a combination therapy with statins is 10 mg – 1 time per day.
In the treatment of fatty acids, used Ezetimibe 10 mg 1 time per day, 2 hours prior to step (sequestrants fatty acids). But no sooner than 4 hours after their admission. Before you order a drug, ask your doctor all the risks associated with taking the drug, especially in combination therapy!
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Side effects of Ezetimibe:
In combination therapy:
– abdominal pain
In combination therapy with a statin:
– abdominal pain
In clinical practice are rare side effects:
– skin rash
Very rare side effects:
– Moderate and severe hepatic impairment
– Simultaneous use with fibrates
– Hypersensitivity to Ezetimibe
– Pregnancy and lactation
If you are pregnant – receiving Ezetimibe should stop!
Ezetimibe well-controlled studies in pregnancy have not been conducted, therefore the use in these patients is not recommended!
Unknown or Ezetimibe is allocated to breast milk. When emergency Ezetimibe use during lactation should stop breastfeeding!
Ezetimibe should not be used for children and adolescents <18 years.
Experimental animal studies:
In animal studies, when administered Ezetimibe did not reveal direct and indirect adverse effects on pregnancy. The development of the fetus and the birth took place without any changes.
When administered to pregnant rats Ezetimibe teratogenic effects were observed. When administered to pregnant rabbits a small frequency observed skeletal malformations in the fetus. It was established that Ezetimibe is displayed with breast milk in lactating rats.
This information can not be used as a guide, this page is for information and talks about the dangers and benefits of the drug Ezetimibe. Before you buy this medication, you should consult a doctor c. We have tried to describe in detail the possible side effects, we hope that this information will help to make a choice.
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