Latin name of substance:

Mometasonum (Mometasoni)

Chemical name of the substance:

(11beta, 16alpha) -9,21-Dichloro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

CAS code

105102-22-5

On this site you can quickly: order / buy; cream / gel; Elocon / Mometasone 5g;

Elocon is a synthetic glucocorticoid used on the skin to relieve itching, inflammation of eczema, dermatitis, allergy and other skin rashes.

Characteristics of the substance Mometasone

Mometasone furoate is a white powder with a yellowish or grayish tinge. Virtually nerastvorim in water, slightly soluble in octanol, moderately – in ethyl alcohol. Molecular weight 521.4.

• Elocon (Mometasone) – 5g/1tubes
• Elocon (Mometasone) – 5g/2tubes
• Elocon (Mometasone) – 5g/3tubes
• Elocon (Mometasone) – 5g/4tubes
• Elocon (Mometasone) – 5g/6tubes
• Elocon (Mometasone) – 5g/6tubes

Pharmacology

Pharmacological action – anti-inflammatory, antiallergic, antipruritic, antiexudative, glucocorticoid.

Induces lipocortins – proteins that inhibit phospholipase A2. As a result, the braking of arachidonic acid from membrane phospholipids is inhibited and biosynthesis of PG, leukotrienes is disrupted.

With intranasal use, systemic bioavailability is less than 0.1% of the dose. The absorption of mometasone from 0.1% cream through the normal skin is 0.4% dose for 8 hours after the application without bandage. In case of inflammation or damage to the skin, absorption accelerates.

With daily application of the cream to children over 2 years old with allergic dermatitis therapeutic effect is manifested in 3 weeks.

Application of the substance mometasone

Locally:

weakening and elimination of inflammatory phenomena and itching in dermatoses (including lesions of hairy areas of skin), amenable to glucocorticoid therapy in adults and children aged 2 years (including psoriasis, atopic dermatitis, seborrheic dermatitis).

Intranasal:

allergic rhinitis (seasonal and year-round) in adults and children aged 2 years, exacerbation of sinusitis (complex therapy with antibiotics) in adults and children over 12 years, prevention of seasonal allergic rhinitis of moderate and severe course in adults and children over 12 years of age (recommended for 2-4 weeks before the expected start of the dusting season).

Inhalation:

bronchial asthma of any severity (including in patients who previously used both inhalation and systemic HA, as well as inadequate efficacy of previous therapy without the use of HA); COPD – from moderate severity to very severe.

What to buy the drug on the over-the-counter (without the prescription / otc):

You need to go to the link to the advertising site, to select the product and fill out the data and the delivery address. Delivery to the USA – within 3 – 4 days.

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Contraindications

Hypersensitivity; for intranasal use: the presence of untreated local infection involving the mucous membrane of the nasal cavity, recent surgery or injury to the nose (until the wound is healed); tuberculosis infection (active or latent) of the respiratory tract, untreated fungal, bacterial, viral systemic infection or infection caused by Herpes simplex with eye damage (as an exception, the appointment of mometasone in these cases is possible on the instructions of the doctor with great care).

Application in pregnancy and lactation

Perhaps, if the expected effect of therapy exceeds the potential risk to the fetus and the baby.

The action category for fetus by FDA is C.

Side effects of the substance mometasone

Locally (ointment, cream, lotion, gel): burning, itching, tingling and tingling sensations, paresthesia, folliculitis, acne vulgaris, skin atrophy, hypertrichosis, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, secondary infection, striae, sweating .

Intranasal:

burning, itching, irritation, dryness and atrophy of the nasal mucosa, nosebleeds, pharyngitis, candidiasis, bronchospasm, secondary infection.

Update of information:

Adverse effects with inhalation

With inhalation application

1.  Most often – candidiasis of the oral cavity, pharyngitis, dysphonia, headache.
2.  Rarely – dry mouth and throat, dyspepsia, weight gain, palpitations.
3.  In some cases, in predisposed patients: the occurrence of hypersensitivity reactions, including rash, hives, itching, erythema, as well as swelling of the eyes, face, lips and throat.
4.  When using inhalation GC for the treatment of bronchial asthma, it is possible to develop bronchospasm and increase the number of wheezing in the lungs immediately after inhalation.
5.  Systemic effects (especially when used in high doses and for a long time): suppression of adrenal cortex function, growth retardation in children and adolescents, demineralization of bone tissue, glaucoma, increased intraocular pressure, development of cataracts.