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The drug Meloxicam belongs to the group of oxicams.
Meloxicam (Mobic) – a non-steroidal anti-inflammatory agent.

The drug Mobic-Meloxicam provides analgesic and anti-inflammatory effects.

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Absorption of Meloxicam:
Meloxicam is absorbed in the digestive tract almost completely.
For internal use of the absolute bio-availability is 89%. After 5-6 hours after administration, the maximum concentration of active compound plasma. After 3-5 days of regular re-dosing is reached equilibrium.
The equilibrium concentration of Meloxicam (Cmin-Cmax) is 0.4-1.0 mg, 7.5 mg when taking the drug inside and 0.8-2.0 mg – when receiving 15 mg of Meloxicam in.
Ingestion not affect Meloxicam absorption from the digestive system.
After intramuscular administration parameter bioavailability is 89% after 60 minutes in plasma is the maximum concentration of the active ingredient. Linear pharmacokinetics characteristic when receiving Meloxicam characterized in dosages – 7.5 mg and 15 mg.

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Excretion Meloxicam:
It is metabolized by liver enzymes. It eliminated by the kidneys and intestines equally. The urine is determined four pharmacologically inactive metabolites of the drug. The main metabolite of up to 60% of the administered or the dose, and is formed by oxidation of the intermediate metabolic forms. In unaltered allocated 9% of 5′-hydroxymethyl Meloxicam.
In vitro studies have shown that metabolic transformation is performed mainly isoenzyme CYP2C9, marginally involved CYP3A4. The rest of the metabolites ranges from 4 to 16% of the dose of Meloxicam and formed by the action of peroxidase.
The half-life within 20 hours. Total plasma clearance of the active substance – of approximately 8 ml per minute.

 

Indications Meloxicam:
– Arthrosis
– Chronic polyarthritis
– arthritis

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Instructions for use Meloxicam tablets:
Meloxicam tablets are taken 1 time a day during meals.
Meloxicam tablet need to drink at least 250 ml of water.

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Dosage:
During exacerbation of arthrosis administered 7.5 mg 1 time per day, the dosage can be increased to 15 mg if the therapeutic effect is insufficient.
Arthritis, administered 15 mg Meloxicam 1 time per day. If there is a sufficient therapeutic effect, the daily dose reduced to 7.5 mg per day. Do not exceed the recommended dose of Meloxicam – 15 mg per day.
For elderly patients, or if necessary, long-term treatment, the recommended dose is 7.5 mg per day.

Side effects:
– anemia
– Blurred vision
– headache
– dizziness
– Diarrhea or constipation
– Itching or rash on the skin
– Swelling

Do not take Meloxicam, if you have:
– ulcer
– Hypersensitivity to the active substance or other ingredients of Meloxicam
– Gastrointestinal bleeding
– pregnancy
– Severe renal or hepatic impairment
– Age <15 years
– Severe heart failure

WARNING: during pregnancy Meloxicam is absolutely contraindicated !!!

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Overdose:
When you receive a dose of 15 mg per day Meloxicam possible drug overdose.

– Seizures
– drowsiness
– abdominal pain
– nausea and vomiting
– Impaired liver function
– High blood pressure
– Rarely develop their bleeding of the gastrointestinal tract.
After an overdose of the drug Meloxicam, patients require maintenance therapy.

Product:
Meloxicam (Mobic) pill 15 mg.

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