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The drug Meloxicam belongs to the group of oxicams.
Meloxicam (Mobic) – a non-steroidal anti-inflammatory agent.
The drug Mobic-Meloxicam provides analgesic and anti-inflammatory effects.
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Absorption of Meloxicam:
Meloxicam is absorbed in the digestive tract almost completely.
For internal use of the absolute bio-availability is 89%. After 5-6 hours after administration, the maximum concentration of active compound plasma. After 3-5 days of regular re-dosing is reached equilibrium.
The equilibrium concentration of Meloxicam (Cmin-Cmax) is 0.4-1.0 mg, 7.5 mg when taking the drug inside and 0.8-2.0 mg – when receiving 15 mg of Meloxicam in.
Ingestion not affect Meloxicam absorption from the digestive system.
After intramuscular administration parameter bioavailability is 89% after 60 minutes in plasma is the maximum concentration of the active ingredient. Linear pharmacokinetics characteristic when receiving Meloxicam characterized in dosages – 7.5 mg and 15 mg.
It is metabolized by liver enzymes. It eliminated by the kidneys and intestines equally. The urine is determined four pharmacologically inactive metabolites of the drug. The main metabolite of up to 60% of the administered or the dose, and is formed by oxidation of the intermediate metabolic forms. In unaltered allocated 9% of 5′-hydroxymethyl Meloxicam.
In vitro studies have shown that metabolic transformation is performed mainly isoenzyme CYP2C9, marginally involved CYP3A4. The rest of the metabolites ranges from 4 to 16% of the dose of Meloxicam and formed by the action of peroxidase.
The half-life within 20 hours. Total plasma clearance of the active substance – of approximately 8 ml per minute.
– Chronic polyarthritis
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Instructions for use Meloxicam tablets:
Meloxicam tablets are taken 1 time a day during meals.
Meloxicam tablet need to drink at least 250 ml of water.
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During exacerbation of arthrosis administered 7.5 mg 1 time per day, the dosage can be increased to 15 mg if the therapeutic effect is insufficient.
Arthritis, administered 15 mg Meloxicam 1 time per day. If there is a sufficient therapeutic effect, the daily dose reduced to 7.5 mg per day. Do not exceed the recommended dose of Meloxicam – 15 mg per day.
For elderly patients, or if necessary, long-term treatment, the recommended dose is 7.5 mg per day.
– Blurred vision
– Diarrhea or constipation
– Itching or rash on the skin
Do not take Meloxicam, if you have:
– Hypersensitivity to the active substance or other ingredients of Meloxicam
– Gastrointestinal bleeding
– Severe renal or hepatic impairment
– Age <15 years
– Severe heart failure
WARNING: during pregnancy Meloxicam is absolutely contraindicated !!!
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When you receive a dose of 15 mg per day Meloxicam possible drug overdose.
– abdominal pain
– nausea and vomiting
– Impaired liver function
– High blood pressure
– Rarely develop their bleeding of the gastrointestinal tract.
After an overdose of the drug Meloxicam, patients require maintenance therapy.
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